Are T-Cell Responses to GAD65 Influential in Type 1 Diabetes?: FIG. 1.
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چکیده
منابع مشابه
Are T-Cell Responses to GAD65 Influential in Type 1 Diabetes?
A utoimmune diabetes in the popular nonobese diabetic (NOD) mouse results from a T-cell– mediated destruction of the insulin-producing -cells (1) and serves as a model for human type 1 diabetes (2,3). The mechanisms that initiate early peri-islet inflammation and the destructive components that arise later specifically targeting -cells occur naturally in NOD mice (2,3). Two obstacles hinder our...
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Human T-cell lymphotropic virus type-I (HTLV-I) was the first human retrovirus associated with malignancy. The prevalence of HTLV-I infection varies significantly in different regions of the world. In this study, the prevalence of HTLV-I infection among ethnic Jews living in Shiraz, South of Iran, was investigated. 286 blood samples were obtained. HTLV-1 antibody assay on serum samples was d...
متن کاملGad65 as an Immunomodulator in Type 1 Diabetes
Type 1 diabetes (T1D) is caused by a deficiency of insulin as a result of an autoimmune destruction of the pancreatic β-cells. A possibility to preserve remaining β-cells in children with newly diagnosed T1D is of great importance since sustained β-cell function is recognized to result in reduced end-organ complications. Glutamic acid decarboxylase 65 (GAD65) is one of the major antigens target...
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ژورنال
عنوان ژورنال: Diabetes
سال: 2009
ISSN: 0012-1797,1939-327X
DOI: 10.2337/db09-1445